$ 32. Another group of 36 hens was provided non-medicated drinking water and used as a control group. Chickens: Safe-Guard AquaSol must be administered orally to chickens via the drinking water at a daily dose of 1 mg/kg BW (0.454 mg/lb) for 5 consecutive days. Chickens: Six pivotal dose confirmation studies and five field effectiveness studies were conducted to evaluate the effectiveness of Safe-Guard AquaSol oral suspension against adult A. galli in broiler chickens and replacement chickens and against A. galli and H.gallinarum in breeding chickens and laying hens. Weaned, growing-finishing pigs of approximately 6 weeks of age were used in the study. The amount of FBZ Suspension administered in drinking water to the study pigs was calculated from pre-treatment body weights. No clinically significant effects related to the administration of Safe-Guard AquaSol were observed for any of the parameters evaluated. Prepare a 1 to 1 dilution (pre-dilution) of Safe-Guard AquaSol in water: 1) Calculate the volume of Safe-Guard AquaSol to be administered daily. Protect from light. The margin of safety in broiler chickens was conducted in 480 broiler chickens. [Note: If more than the required amount of the product is accidently poured into the measuring device, discard the entire contents and repeat the process from Step 3 above.]. The aquasol is formulated to be mixed in water, so it will stay suspended correctly. A sixth dose confirmation study was conducted in the US using 176 Ross breed broiler chickens (4 to 5 weeks old). Safe-Guard AquaSol was administered orally as medicated drinking water to three groups of 120 chickens (60 male and 60 female in each group) at 1, 3, and 5 mg fenbendazole/kg body weight/day (1, 3, and 5 times the recommended label dose) for 15 consecutive days . Adult T.suis worms attached to the tract and in the contents of the tract were counted. Adequacy of infection was demonstrated at both study sites by having more than 6 non-medicated pigs (11 of the 12 non-medicated animals in MN and 9 of the 12 non-medicated animals in CA) with adult T. suis worm counts of 100 or more per animal. Fenbendazole (active ingred.) made in China. Each mL of Safe-Guard AquaSol contains 200 mg of fenbendazole. For a better experience, please enable JavaScript in your browser before proceeding. Net volume 1 Liter, Set id: 62bd7997-81e5-46ca-806c-7407344449ae. The feed did not contain antibiotics, anthelmintics, or any other medication. The daily dose of 2.2 mg fenbendazole per kg BW (1 mg/lb) which is equivalent to 0.011mL Safe-Guard AquaSol per kg BW (0.0045 mL/lb).The required daily volume of product is calculated from the total estimated body weight [kg] of the entire group of pigs to be treated. For customer service, adverse effects reporting, and/or a copy of the SDS, call 1-800-211-3573. Another group of 110 breeding chickens (10 male and 100 female) were provided non-medicated drinking water and used as a control group. Housing, management, and husbandry procedures were typical of commercial production practice. Distributed by: Intervet Inc., 2 Giralda Farms, Madison, NJ 07940, Copyright 2023 Animalytix LLC. Chickens: Two margin of safety studies (growing broiler chickens and laying hens at peak egg production) and one reproductive safety study (broiler breeder chickens) were conducted. Use within 6 months after opening. DESCRIPTION: Safe-Guard AquaSol is a suspension concentrate containing fenbendazole, an antiparasitic. Look for telltale symptoms such as reduced feed intake, diarrhea, weight loss or gain, depression, and even decreased egg production among hens. The parasite management plan should be adjusted accordingly based on regular monitoring. You can consult your veterinarian or run tests in diagnostic labs to check whether your chickens have high worm count. The efficacy against adult A. galli and H. gallinarum was 97.6% and 95.3%, respectively. Safe-Guard AquaSol was initially approved in October 2015 for the treatment and control of adult A. galli in broiler chickens and replacement chickens intended to become breeding chickens and for the treatment and control of adult A. galli and H. gallinarum in breeding chickens. Safe-Guard AquaSol should always be measured by adding it to a measuring device that already contains an equivalent volume of water.]. No further stirring during administration is necessary. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Safe-Guard AquaSol was administered orally as medicated drinking water to a group of 110 breeding chickens (10 male and 100 female) at 3 mg fenbendazole/kg body weight/day (3 times the recommended label dose) for 21 consecutive days (4 times the recommended duration). All dewormers require accurate dosing for best results. Once opened, do not store the container above 25C (77F). This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Barrow and gilt breeds representative of U.S. commercial production were used. The chickens were necropsied 7 to 8 days after the last treatment, and adult worms in the intestines and ceca of the chickens in the control and treated groups were counted to determine percent efficacy. No withdrawal period is required when used according to labeling. Safe-Guard Multi-Species Dewormer, Pellets. for 5 consecutive days. The pivotal dose confirmation studies and field effectiveness studies demonstrated substantial evidence of effectiveness of Safe-Guard AquaSol at the dose of 1 mg fenbendazole/kg body weight/day for 5 consecutive days against adult A. galli in broiler chickens and replacement chickens and against adult A. galli and H. gallinarum in breeding chickens and laying hens. At the end of the treatment phase, gross necropsies were performed on 48 chickens from each group, and organs weights were evaluated. Use the medicated water within 24 hours. Safe-Guard AquaSol must be administered orally to chickens via the drinking water at a daily dose of 1 mg/kg BW (0.454 mg/lb) for 5 consecutive days. A fifth effectiveness study was conducted in the US using 550 Cobb breed broiler chickens (4 to 5 weeks old). Each mL of Safe-Guard AquaSol contains 200 mg of fenbendazole. Important: Always read and follow instructions provided by the manufacturer as concentration and dosage can change! Here is an example of calculations depending on the total body weight of the chickens to be treated:if(typeof ez_ad_units != 'undefined'){ez_ad_units.push([[336,280],'farmandchill_com-large-mobile-banner-1','ezslot_7',108,'0','0'])};__ez_fad_position('div-gpt-ad-farmandchill_com-large-mobile-banner-1-0'); You can start deworming chicks when they reach 3 months old or as soon as you see worms in their feces. Safe-Guard AquaSol was initially approved in October 2015 for the treatment and control of adult A. galli in broiler chickens and replacement chickens intended to become breeding chickens and for the treatment and control of adult A. galli and H. gallinarum in breeding chickens. Easily administered by medicators or proportioners. No further stirring during administration is necessary. [Note: If more than the required amount of the product is accidently poured into the measuring device, discard the entire contents and repeat the process from Step 3 above.]. SAFE-GUARD AquaSol is a suspension concentrate containing fenbendazole, an antiparasitic. The large roundworm, Ascaridia galli is the most common intestinal parasite found in backyard and free range chicken flocks worldwide. Safeguard is usually administered orally, I do it with an oral syringe. Swine: Animal safety was established using a combination of swine pharmacokinetic, physiologic, and pharmacologic data that provided a basis for bridging the safety data of Safe-Guard Type A medicated article (NADA 131-675) to Safe-Guard AquaSol oral suspension in swine. Housing, management, and husbandry procedures were typical of commercial production practice. The reproductive safety in broiler breeding chickens was conducted in 220 broiler breeder chickens. During treatment, all animals must have sole and unrestricted access to the medicated water. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Swine: Swine intended for human consumption must not be slaughtered within 2 days from the last treatment. Follow the instructions in the order described below to prepare the medicated water. ANIMAL SAFETY: Two margin of safety studies (growing broiler chickens and laying hens at peak egg production) and one reproductive safety study (broiler breeder chickens) were conducted. Consult your Veterinarian for assistance in the diagnosis, treatment, and control of parasitism. USER SAFETY WARNINGS: Not for use in humans. During treatment all chickens must have sole and unrestricted access to the medicated water. Please use the following formula: Prepare a 1 to 1 dilution (pre-dilution) of Safe-Guard AquaSol in water: 1) Calculate the volume of Safe-Guard AquaSol to be administered daily. A sixth dose confirmation study was conducted in the US using 176 Ross breed broiler chickens (4 to 5 weeks old). The margin of safety in laying hens was conducted in 144 laying hens. Stir the medicated water in the medication tank until the medicated water is visibly homogeneous. To anyone thinking of getting one of those cute little coops. After complete consumption of the medicated water, the chickens should have access to non-medicated drinking water ad libitum. Safe-Guard AquaSol is indicated for the treatment and control of adult Ascaridia galli in broilerchickens and replacement chickens intended to become breeding chickens and for thetreatment and control of adult A. galli and Heterakis gallinarum in breeding chickens. It is also available as a water-soluble paste for feeding chickens. A field effectiveness study was conducted in the EU in a flock of 13,244 Hy-Line layer breed replacement chickens (13 weeks old). The recommended dose calculation is 1 milligram of fenbendazole per 1-kilogram chicken body weight. USER SAFETY WARNINGS: Not for use in humans. I happen to have a 10 ml pipet and a 100 ml volumetric flask as well as 1 ml and 3 ml syringes so it's rather simple for me to do the dilutions. You can purchase it at your local supermarkets, grocery stores, and pet stores. RESIDUE WARNING: No withdrawal period is required when used according to labeling. The parasite management plan should be adjusted accordingly based on regular monitoring. These studies supported the safety of Safe-Guard AquaSol in broiler chickens, replacement chickens, laying hens and breeding chickens when administered in drinking water at 1 mg fenbendazole/kg body weight/day for 5 consecutive days. Dosage is specified as 0.005 milliliters of Safe-Guard Aquasol per 1-kilogram chicken body weight in a day, for 5 consecutive days. Safe-Guard AquaSol was administered orally as medicated drinking water to a group of 110 breeding chickens (10 male and 100 female) at 3 mg fenbendazole/kg body weight/day (3 times the recommended label dose) for 21 consecutive days (4 times the recommended duration). 2) Select a measuring device capable of accurately measuring a volume of at least twice the calculated Safe-Guard AquaSol daily volume. Zhejiang Apeloa Kangyu Pharmaceutical Co., Ltd. Six pens of 2 pigs each were used per treatment group. The following are organic dewormers for chickens that are based on anecdotal information and have not been fully investigated in a research setting: Safeguard is safe to use for controlling and treating intestinal worms in chickens. Chickens: Six pivotal dose confirmation studies and five field effectiveness studies were conducted to evaluate the effectiveness of Safe-Guard AquaSol oral suspension against adult A. galli in broiler chickens and replacement chickens and against A. galli and H. gallinarum in breeding chickens and laying hens. Loading reviews. Protective gloves should be used and care should be taken when handling the product to avoid skin and eye exposure and accidental ingestion. Emergencies / Diseases / Injuries and Cures, https://animaldrugsatfda.fda.gov/adafda/app/search/public/document/downloadFoi/3083, https://www.backyardchickens.com/threads/safeguard-mash-zero-day-egg-withdrawal.1254653/, Question on Safe-Guard vs Aquasol product info. The efficacy against adult A. galli was 90.2%. It IS possible to have a false negative test depending on where in the life cycle the parasites are. Fifteen chickens were necropsied before treatment initiation, and 15 chickens were necropsied seven days after treatment for worm counts. Use the medicated water within 24 hours. The volume of water in the stock suspension container has to be calculated taking as a basis the present injection rate of the dosing pump and the volume of drinking water usually consumed by the animals over a period of 3 to 24 hours. Safe-Guard AquaSol for Chickens Indications. Individual fecal samples were obtained from each candidate animal 46, 47, and 48 days after T. suis inoculation and analyzed for the presence of T. suis eggs. safe-guard AquaSol (fenbendazole oral suspension). The reproductive safety in broiler breeding chickens was conducted in 220 broiler breeder chickens. It is the active ingredient used in Safe-Guard Aquasol, and it works to combat adult-stage roundworms and adult-stage cecal worms in chickens. A fourth field effectiveness study was conducted in the US using 550 Cobb breed breeder hens (63 weeks old). Palatability: A pivotal palatability study was conducted to evaluate the palatability of 20% Fenbendazole Suspension in pigs through voluntary consumption of medicated water when offered for approximately 5 hours a day over 3 consecutive days at a dose of 2.2mg fenbendazole/kg body weight (BW) per day (label dose). 3.0. [Note: If the total volume of the 1 to 1 dilution needed exceeds the volume of the largest available measuring device, divide the total volume into two or more smaller batches of 1 to 1 dilution, prepared following the steps below. A fifth dose confirmation study was conducted in the US using 176 Cobb breed broiler chickens (4 to 5 weeks old). The percent reduction in T. suis worm counts in the FBZ medicated animals was greater than 90% (98.5% in MN and 98.6% in CA) compared to the non-medicated animals using transformed data (geometric means). In the study, the efficacy against adult A. galli was 100%. For additional information about adverse drug experience reporting for animal drugs, contact FDA at 1-888-FDA-VETS, or http://www.fda.gov/AnimalVeterinary/SafetyHealth. Please use the following formula: Total estimated body weight [kg] of the pigs to be treated x 0.0.011 mL = mL Safe-Guard AquaSol/day, Volume of Safe-Guard AquaSol (for 3 days). In the study, the efficacy against adult A. galli and H. gallinarum was 98.7% and 99.2%, respectively. For Patent Information: http://www.merck.com/product/patent/home.html. Zyfend A, 30 mL. In all chickens, feed and water intake, body weights, clinical health, and mortality were recorded. Affiliate Disclosure GTIN#/UPC#. 2023 Best Veterinary Solutions, Inc.All Rights Reserved. If the administration period exceeds 8 hours, but being no longer than 24 hours, the stock suspension container needs to be equipped with a stirring device. It is a yellowish white, thick worm which can grow up to 115 mm (4.5 inches) in length. Aquasol is 200mg fenbendazole/ml of product (20%) -> recommendations from the product bulletin and the US National Lib. A fourth field effectiveness study was conducted in the US using 550 Cobb breed breeder hens (63 weeks old). Do not freeze. 99. Worms can infect the feces and intestinal tracts of older chickens and will subsequently infect their chicks. Safe-Guard AquaSol for Chickens Indications, Warnings and cautions for Safe-Guard AquaSol for Chickens, Direction and dosage information for Safe-Guard AquaSol for Chickens. JavaScript seems to be disabled in your browser. No clinically significant effects related to the administration of Safe Guard AquaSol were observed for any of the parameters evaluated. 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Of accurately measuring a volume of at least twice the calculated Safe-Guard AquaSol is to! Eu in a day, for 5 consecutive days provided non-medicated drinking water to the study, efficacy.: no withdrawal period is required when used according to labeling breed broiler chickens ( 13 weeks ). Combat adult-stage roundworms safeguard aquasol for chickens adult-stage cecal worms in chickens net volume 1 Liter Set... Fenbendazole, an antiparasitic, Ascaridia galli is the most common intestinal parasite found in backyard and free range flocks! Calculated Safe-Guard AquaSol contains 200 mg of fenbendazole of FBZ safeguard aquasol for chickens administered in water! Product to avoid skin and eye exposure and accidental ingestion ingredient used in the diagnosis, treatment all!
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