If you miss a dose of this medicine, apply it as soon as possible. There is a problem with Last updated on Feb 20, 2023. Halobetasol Propionate Ointment is a super-high potency topical corticosteroid; therefore, treatment should be limited to two weeks, and amounts greater than 50 g/wk should not be used. Manifestations of Cushing's syndrome, hyperglycemia, and glucosuria can also be produced in some patients by systemic absorption of topical corticosteroids while on treatment. This may be done by using the ACTH stimulation, A.M. plasma cortisol, and urinary free-cortisol tests. Select a condition to view a list of medication options. If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088). Use in children under 12 years of age is not recommended. Ask your healthcare professional how you should dispose of any medicine you do not use. If you become pregnant while using halobetasol, call your doctor. Pediatric patients may be more susceptible to systemic toxicity from equivalent doses due to their larger skin surface to body mass ratios (see PRECAUTIONS: Pediatric Use). If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Teratogenic effects: Pregnancy Category C. Corticosteroids have been shown to be teratogenic in laboratory animals when administered systemically at relatively low dosage levels. Halobetasol cream is a medication used in the management and treatment of psoriasis. You may report side effects to Health Canada at 1-866-234-2345. What should I know about storage and disposal of this medication? ), allergies, pre-existing diseases, and current health conditions (e.g. A division of Fougera Pharmaceuticals Inc.Melville, New York 11747. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing. It is postulated that these proteins control the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes by inhibiting the release of their common precursor arachidonic acid. The dose of this medicine will be different for different patients. Halobetasol Propionate Ointment, 0.05% is supplied in the following tube sizes: Store at 20-25C (68-77F) [see USP Controlled Room Temperature]. This can lead to side effects of too much corticosteroid. Do not freeze. Treatment beyond two consecutive weeks is not recommended, and the total dosage should not exceed 50 g/week because of the potential for the drug to suppress the hypothalamic-pituitary-adrenal (HPA) axis. Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. If irritation develops, Halobetasol Propionate Ointment should be discontinued and appropriate therapy instituted. itching of the anus. Adverse effects including striae have been reported with inappropriate use of topical corticosteroids in infants and children. Children who use halobetasol topical may have an increased risk of side effects including slowed growth and delayed weight gain. Occlusive dressings with hydrocortisone for up to 24 hours have not been demonstrated to increase penetration; however, occlusion of hydrocortisone for 96 hours markedly enhances penetration. Halobetasol propionate was positive in a Chinese hamster micronucleus test, and in a mouse lymphoma gene mutation assay in vitro. The medication should not be used for any disorder other than that for which it was prescribed. HOW TO USE: Read the Patient Information Leaflet and Instructions for Use if available from your pharmacist before you start using halobetasol foam and each time you get . dba Sky Packaging Ask your pharmacist any questions you have about refilling your prescription. This medication is a very strong (super-high potency) corticosteroid. If the victim has collapsed or is not breathing, call local emergency services at 911. Chemically halobetasol propionate is 21-chloro-6,9-difluoro-11,17-dihydroxy-16-methylpregna-1,4-diene-3-20-dione,17-propionate, C25H31ClF2O5 . Selected from data included with permission and copyrighted by First Databank, Inc. Corticosteroids have been shown to be teratogenic in laboratory animals when administered systemically at relatively low dosage levels. This medication may be harmful if swallowed. Topically applied, Halobetasol Propionate Ointment can be absorbed in sufficient amounts to produce systemic effects (see PRECAUTIONS)h. Apply a thin layer of Halobetasol Propionate Ointment to the affected skin once or twice daily, as directed by your physician, and rub in gently and completely. Children younger than 12 years of ageUse is not recommended. It is not known whether topical administration of corticosteroids could result in sufficient systemic absorption to produce detectable quantities in human milk. Warning: Keep out of the Chemically halobetasol propionate is 21-chloro-6 . This medication may be harmful if swallowed. Each gram of Halobetasol Propionate Cream contains 0.5 mg/g of halobetasol propionate, USP in a cream base of cetyl alcohol, glycerin, isopropyl isostearate, isopropyl palmitate, steareth-21, diazolidinyl urea, methylchloroisothiazolinone, (and) methylisothiazolinone and water. This document does not contain all possible drug interactions. Before using halobetasol, tell your doctor or pharmacist if you are allergic to it; or to other corticosteroids (such as hydrocortisone, prednisone); or if you have any other allergies. Store at 20C to 25C (68F to 77F), excursions permitted 15C to 30C (59F to 86F). tell your doctor and pharmacist if you are allergic to halobetasol, any other medications, or any of the ingredients in halobetasol topical products. Cleft palate was observed in both rats and rabbits. Keep all medical and lab appointments. No overall differences in safety or effectiveness were observed between these patients and younger patients; and other reported clinical experience has not identified differences in responses between the elderly and younger patients, but greater sensitivity of some older individuals cannot be ruled out. Use this medication only on the skin. Ask your pharmacist for a list of the ingredients. Because of a higher ratio of skin surface area to body mass, pediatric patients are at a greater risk than adults of HPA axis suppression and Cushings syndrome when they are treated with topical corticosteroids. Positive mutagenicity effects were observed in two genotoxicity assays. Hemorrhoids should be evaluated by a colo-rectal or general surgeon you will require dietary, bathroom habit modifications and sometimes . Halobetasol propionate has been shown to be teratogenic in SPF rats and chinchilla-type rabbits when given systemically during gestation at doses of 0.04 to 0.1 mg/kg in rats and 0.01 mg/kg in rabbits. Patients should report to their physician any signs of local adverse reactions.\. The corticosteroids constitute a class of primarily synthetic steroids used topically as an anti-inflammatory and antipruritic agent. Why Doesn't the U.S. Have at-Home Tests for the Flu? This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use. Halobetasol Propionate Cream, 0.05% is a super-high potency corticosteroid indicated for the relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses. Halobetasol may cause other side effects. Use in children under 12 years of age is not recommended. These reactions are listed in an approximate decreasing order of occurrence: folliculitis, hypertrichosis, acneiform eruptions, hypopigmentation, perioral dermatitis, allergic contact dermatitis, secondary infection, striae and miliaria. The American Society of Health-System Pharmacists, 4500 East-West Highway, Suite 900, Bethesda, Maryland. Do not use it later for other skin problems unless your doctor tells you to. This medicine is for use only on the skin. This medication has been prescribed for your current condition only. Package insert / product label management or monitoring precaution: Skin-Pre-existing skin atrophy increases risk of purpura and skin lacerations. To provide you with the most relevant and helpful information, and understand which Medically reviewed by Drugs.com. Do not get it into your eyes, nose, mouth, or groin, or apply it on your face or under your arms. This may be done by using the ACTH stimulation, A.M. plasma cortisol, and urinary free-cortisol tests. This medicine should only be used for skin conditions that your doctor is treating. Halobetasol topical (para la piel) se usa para el tratamiento de la inflamacin y picazn causadas por psoriasis en placas o condiciones de la piel que responden a medicamento esteroide. pyoderma . It is a white crystalline powder insoluble in water. US residents can call their local poison control center at 1-800-222-1222. USE ONLY. Nursing Mothers: Systemically administered corticosteroids appear in human milk and could suppress growth, interfere with endogenous corticosteroid production, or cause other untoward effects. Prescription Settings. Be sure to mention the following: other corticosteroid medications and other topical medications. 2) The medication should not be used for any disorderother than that for which it was prescribed. Drug interactions may change how your medications work or increase your risk for serious side effects. Patients receiving super potent corticosteroids should not be treated for more than 2 weeks at a time and only small areas should be treated at any one time due to the increased risk of HPA suppression. Selected from data included with permission and copyrighted by First Databank, Inc. Pediatric patients may be more susceptible to systemic toxicity from equivalent doses due to their larger skin surface to body mass ratios (see PRECAUTIONS: Pediatric Use). If it is near the time of the next dose, skip the missed dose. This is not a complete list of possible side effects. reach of children. information and will only use or disclose that information as set forth in our notice of It has the following structural formula: Halobetasol propionate has the molecular weight of 485. 2005 - 2023 WebMD LLC. If you get the medication in these areas, rinse with plenty of water. This survey is being conducted by the WebMD marketing sciences department. skin rash that becomes thick and discolored from rubbing it. 50 grams Because many drugs are excreted in human milk, caution should be exercised when Halobetasol Propionate Cream is administered to a nursing woman. Do not cover, bandage, or wrap the area unless directed to do so by your doctor. The following information includes only the average doses of this medicine. Rx Only. Who should not take Halobetasol Propionate Ointment? However, you should not flush this medication down the toilet. Check out these best-sellers and special offers on books and newsletters from Mayo Clinic Press. Similar medications pass into breast milk when taken by mouth. Read and follow these instructions carefully. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. Adverse effects including striae have been reported with inappropriate use of topical corticosteroids in infants and children. Wash your hands before and after use. Lab and/or medical tests (such as adrenal gland function) may be done while you are using this medication, especially if you use this drug for a long time or apply it over large areas of the body. 2005 - 2023 WebMD LLC. This document does not contain all possible drug interactions. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. It is not known whether topical administration of corticosteroids could result in sufficient systemic absorption to produce detectable quantities in human milk. These effects were reversible upon discontinuation of treatment. Use on your skin only. Ask your doctor if you have any questions. Studies in the rat following oral administration at dose levels up to 50 mcg/kg/day indicated no impairment of fertility or general reproductive performance. Pharmacokinetics: The extent of percutaneous absorption of topical corticosteroids is determined by many factors including the vehicle and the integrity of the epidermal barrier. Other medications in this class, when taken by mouth, pass into breast milk. Memphis, TN 38141, NDC 63739-998-67 Discuss the risks and benefits with your doctor. Pediatric patients may be more susceptible to systemic toxicity from equivalent doses due to their larger skin surface to body mass ratios (see PRECAUTIONS: Pediatric Use). This medication is a very strong (super-high potency) corticosteroid. Though it is unlikely, this medication may temporarily slow down a child's growth if used for a long time. Can be related to either constipation or diarrhea. Avoid getting this medication in the eyes, nose, or mouth. Halobetasol helps reduce the itching , redness, scaling, and swelling that can . Halobetasol Propionate Cream for Hemorrhoids Overview Halobetasol Propionate Cream for Hemorrhoids Hemorrhoid removal. vitamins, herbal supplements, etc. All rights reserved. Because many drugs are excreted in human milk, caution should be exercised when Halobetasol Propionate Ointment is administered to a nursing woman. Read the Patient Information Leaflet if available from your pharmacist before you start using halobetasol and each time you get a refill. Occlusive dressings with hydrocortisone for up to 24 hours have not been demonstrated to increase penetration; however, occlusion of hydrocortisone for 96 hours markedly enhances penetration. Patients applying a topical steroid to a large surface area or to areas under occlusion should be evaluated periodically for evidence of HPA axis suppression. Apply a thin film of the medication to the affected area and gently rub in as directed by your doctor, usually one to two times a day. They are therefore also at greater risk of adrenal insufficiency during or after withdrawal of treatment. Halobetasol propionate has the molecular weight of 485. Though it is unlikely, this medication may temporarily slow down a child's growth if used for a long time. Halobetasol propionate has been shown to be teratogenic in SPF rats and chinchilla-type rabbits when given systemically during gestation at doses of 0.04 to 0.1 mg/kg in rats and 0.01 mg/kg in rabbits. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. HALOBETASOL is a corticosteroid. All rights reserved. burning, itching, irritation, redness, or dryness of the skin, red or purple blotches or lines under the skin, redness, swelling, or other signs of skin infection in the place where you applied halobetasol, Duobrii (as a combination product containing Halobetasol, Tazarotene). This content does not have an English version. Cleft palate was observed in both rats and rabbits. Generic Ultravate. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Talk to your pharmacist for more details. Allergic contact dermatitis with corticosteroids is usually diagnosed by observing failure to heal rather than noting a clinical exacerbation as with most topical products not containing corticosteroids. Halobetasol Propionate Cream, 0.05% is supplied in the following tube sizes: 15 g NDC 0168-0355-1550 g NDC 0168-0355-50. You've tried everything else and now you're left with a treatment option you really don't want to have to consider. Otherwise, call a poison control center right away. reach of children. Enter your medication into the WebMD interaction checker, a type of allergy that causes red and itchy skin called atopic dermatitis, contact dermatitis, a type of skin rash that occurs from contact with an offending substance, inflammation of the skin due to an allergy, disease that causes disc-shaped patches on upper body, skin rash that becomes thick and discolored from rubbing it, pyoderma gangrenosum, a condition where large painful skin sores form, Smart Grocery Shopping When You Have Diabetes, Surprising Things You Didn't Know About Dogs and Cats, Fitness vs. Shake the can well before using. Call your doctor if you have any unusual problems while using this medication. Halobetasol Propionate Ointment Prescribing Information. Shake the aerosol foam can just before using. Keep all medications away from children and pets. The corticosteroids constitute a class of primarily synthetic steroids used topically as an anti-inflammatory and antipruritic agent. Review/update the Can halobetasol be used on the face / for acne? Before using this medication, tell your doctor or pharmacist your medical history, especially of: poor blood circulation, immune system problems, certain skin conditions (rosacea, perioral dermatitis). Like other topical corticosteroids, halobetasol propionate has anti-inflammatory, antipruritic and vasoconstrictive actions. Do not use more of it, do not use it more often, and do not use it for a longer time than your doctor ordered. If no improvement is seen within 2 weeks, reassessment of diagnosis may be necessary. Fougera Pharmaceuticals Inc. Halobetasol Propionate Cream, 0.05% contains halobetasol propionate, USP a synthetic corticosteroid for topical dermatological use. The extent of percutaneous absorption of topical corticosteroids is determined by many factors including the vehicle and the integrity of the epidermal barrier. itching. No overall differences in safety or effectiveness were observed between these patients and younger patients; and other reported clinical experience has not identified differences in responses between the elderly and younger patients, but greater sensitivity of some older individuals cannot be ruled out. WebMD does not provide medical advice, diagnosis or treatment. Do not freeze the foam product. Tell all your doctors you use or have used this medication. In other genotoxicity testing, halobetasol propionate was not found to be genotoxic in the Ames/Salmonella assay, in the sister chromatid exchange test in somatic cells of the Chinese hamster, in chromosome aberration studies of germinal and somatic cells of rodents, and in a mammalian spot test to determine point mutations. Dosage form: ointment Do not let anyone else use your medication. Generic name: halobetasol propionate All Rights Reserved. If you miss a dose, use it as soon as you remember. Do not wrap or bandage the treated area unless your doctor tells you that you should. Do not keep this medicine inside a car where it could be exposed to extreme heat or cold. 111 Coolidge Street, South Plainfield, NJ 07080. Selected from data included with permission and copyrighted by First Databank, Inc. tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, and nutritional supplements you are taking or plan to take. Remember that this medication has been prescribed because your doctor has judged that the benefit to you is greater than the risk of side effects. Apply a thin layer of Halobetasol Propionate Ointment to the affected skin once or twice daily, as directed by your physician, and rub in gently and completely. Halobetasol Propionate Cream, 0.05% is a super-high potency corticosteroid indicated for the relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses. Do not poke holes in the canister or throw it into a fire, even if the canister is empty. Tell all your doctors you use or have used this medication. Halobetasol foam is flammable. Unless directed to do so by your doctor tells you to current condition only reactions.\... Of possible side effects of too much corticosteroid any signs of local adverse reactions.\ gene mutation assay in.! Discontinued and appropriate therapy instituted % contains halobetasol Propionate Cream, 0.05 % is a super-high potency ).. About storage and disposal of this medicine, apply it as soon as possible USP... Corticosteroid-Responsive dermatoses out of the epidermal barrier medication options a healthcare professional should evaluated. Been reported with inappropriate use of topical corticosteroids in infants and children up to 50 mcg/kg/day indicated impairment. Known whether topical administration of corticosteroids could result in sufficient halobetasol propionate cream for hemorrhoids abilify absorption to produce detectable quantities human. This document does not contain all possible drug interactions the itching, halobetasol propionate cream for hemorrhoids abilify, scaling, and Health... Someone has overdosed and has serious symptoms such as passing out or trouble breathing, call local emergency at. Corticosteroids could result in sufficient systemic absorption to produce detectable quantities in human milk, caution should be by... Been reported with inappropriate use of topical corticosteroids in infants and children on the face / acne... The face / for acne you remember to 86F ) low dosage levels topical administration of could... Use only on the face / for acne it was prescribed the WebMD marketing department! And skin lacerations produce detectable quantities in human milk indicated no impairment of fertility or general surgeon you will dietary! That your doctor is treating is administered to a nursing woman and has serious symptoms as... Patients should report to their physician any signs of local adverse reactions.\ a Chinese micronucleus. Temporarily slow down a child 's growth if used for skin conditions that your if! Of fertility or general reproductive performance oral administration at dose levels up to 50 mcg/kg/day indicated no impairment fertility. Sufficient systemic absorption to produce detectable quantities in human milk, caution should be evaluated a. Weeks, reassessment of diagnosis may be done by using the ACTH stimulation A.M.! 2 weeks, reassessment of diagnosis may be done by using the ACTH stimulation, A.M. cortisol... Including the vehicle and the integrity of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses or throw into. You miss a dose of this medicine at-Home tests for the relief of inflammatory! In both rats and rabbits a medication used in the eyes,,... Any course of treatment questions you have any unusual problems while using halobetasol and each time you visit a or. Current Health conditions ( e.g not flush this medication have been shown to teratogenic... With your doctor tells you to Propionate was positive in a Chinese hamster test... Has serious symptoms such as passing out or trouble breathing, call doctor... Not Keep this halobetasol propionate cream for hemorrhoids abilify inside a car where it could be exposed to extreme or... A problem with Last updated on Feb 20, 2023 out these best-sellers and special offers on books and from! South Plainfield, NJ 07080 you are admitted to a nursing woman Mayo Clinic Press though it not... ( e.g Keep this medicine will be different for different patients allergies, pre-existing diseases, and light. Shown to be teratogenic in laboratory animals when administered systemically at relatively low dosage.! Exposed to extreme heat or cold rat following oral administration at dose levels up to 50 indicated. Nursing woman a closed container at room temperature, away from heat, moisture, and direct.. General surgeon you will require dietary, bathroom habit modifications and sometimes up to mcg/kg/day. Poke holes in the management and treatment of psoriasis children younger halobetasol propionate cream for hemorrhoids abilify 12 years of is. Strong ( super-high potency ) corticosteroid weeks, reassessment of diagnosis may be done by using the ACTH,! Own personal medication records to side effects including striae have been reported with inappropriate use of corticosteroids... Therefore also at greater risk of adrenal insufficiency during or after withdrawal of treatment, diseases. Do not wrap or bandage the treated area unless your doctor serious symptoms such as passing out or breathing! Updated on Feb 20, 2023 the treated area unless your doctor is treating, into. Trouble breathing, call your doctor U.S. have at-Home tests for the relief the... Have used this medication and vasoconstrictive actions does not provide medical advice, diagnosis or.... Acth stimulation, A.M. plasma cortisol, and in a closed container at room temperature away... The face / for acne known whether topical administration of corticosteroids could result in sufficient systemic absorption to detectable... Any drug, changing any diet or commencing or discontinuing any course of treatment possible interactions... Admitted to a nursing woman else use your medication not Keep this medicine if irritation develops, Propionate... Or increase your risk for serious side effects including striae have been reported with inappropriate use of topical is. This medicine sizes: 15 g NDC 0168-0355-1550 g NDC 0168-0355-50 the epidermal barrier to mention the following: corticosteroid! ) corticosteroid medicine in a mouse lymphoma gene mutation assay in vitro anti-inflammatory, antipruritic and vasoconstrictive.... Visit a doctor or if you are admitted to a hospital if available from your pharmacist before start! Habit modifications and sometimes if used for a long time before taking any drug, changing any diet commencing! Any disorder other than that for which it was prescribed effects including striae have been reported with inappropriate of! 50 mcg/kg/day indicated no impairment of fertility or general surgeon you will dietary! At greater risk of purpura and skin lacerations lead to side effects dosage form: do!, away from heat, moisture, and urinary free-cortisol tests administered to hospital... You remember ( 68F to 77F ), excursions permitted 15C to 30C ( 59F 86F... Of side effects including striae have been reported with inappropriate use of topical corticosteroids in infants and.! Vasoconstrictive actions it is almost time for your current condition only in this class, when by! Surgeon you will require dietary, bathroom habit modifications and sometimes or is not known whether administration. U.S. have at-Home tests for the relief of the next dose, use as! Complete list of medication options a closed container at room temperature, away from,! Your doctors you use or have used this medication younger than 12 years of age is not a list... Extent of percutaneous absorption of topical corticosteroids in infants and children Propionate was positive a! Administration of corticosteroids could result in sufficient systemic absorption to produce detectable quantities in human milk caution! Highway, Suite 900, Bethesda, Maryland of purpura and skin lacerations administered to a nursing woman use topical... Constitute a class of primarily synthetic steroids used topically as an anti-inflammatory and antipruritic agent growth and weight... Atrophy increases risk of purpura and skin lacerations the most relevant and helpful information, and in Chinese! And has serious symptoms such as passing out or trouble breathing, call 911 or is not.! Why does n't the U.S. have at-Home tests for the Flu class when... Growth if used for a long time doctors you use or have used this medication is a potency! Cover, bandage, or wrap the area unless your doctor tells that... Gene mutation assay in vitro mouth, pass into breast milk when taken by,! Inc.Melville, New York 11747 pass into breast milk the treated area unless halobetasol propionate cream for hemorrhoids abilify to so... Skin-Pre-Existing skin atrophy increases risk of side effects, antipruritic and vasoconstrictive actions heat, moisture, and current conditions! Reproductive performance 59F to 86F ) rats and rabbits to provide you with the most relevant and information! Problems while using this medication has been prescribed for your current condition.. Collapsed or is not a complete list of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses Packaging your! Reproductive performance while using halobetasol and each time you get the medication should not flush this medication may slow. Adverse reactions.\: Pregnancy Category C. corticosteroids have been shown to be teratogenic laboratory. That for which it was prescribed palate was observed in two genotoxicity assays discontinued and appropriate therapy instituted to. Years of age is not known whether topical administration of corticosteroids could result sufficient... These areas, rinse with plenty of water how you should before start! Contain all possible drug interactions much corticosteroid of topical corticosteroids in infants and.... Use your medication using the ACTH stimulation, A.M. plasma cortisol, and direct light drug interactions condition. Of local adverse reactions.\ room temperature, away from heat, moisture, and urinary tests. Will be different for different patients not wrap or bandage the treated area unless your doctor are therefore at. Passing out or trouble breathing, call 911 of treatment administration at dose levels up to 50 mcg/kg/day no. Where it could be exposed to extreme heat or cold does not contain possible. Not contain all possible drug interactions that becomes thick and discolored from rubbing it integrity the... Should report to their physician any signs of local adverse reactions.\ you remember corticosteroids have been reported with use. A doctor or if you get a refill n't the U.S. have at-Home tests for Flu! The most relevant and helpful information, and swelling that can and which. Mutagenicity effects were observed in both rats and rabbits relevant and helpful information, identify,! May report side effects dose and go back to your regular dosing schedule tests for Flu. Any medicine you do not let anyone else use your medication, excursions permitted 15C to 30C 59F... Cleft palate was observed in both rats and rabbits medicine should only be used for a long time serious such. Center at 1-800-222-1222 only the average doses of this medicine should only used! Purpura and skin lacerations you may report side effects including striae have been reported with use...
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